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Related Experiment Videos

Physiological and morphological changes in developing peripheral nerves of rat embryos.

L Ziskind-Conhaim1

  • 1Department of Physiology, University of Wisconsin, Madison 53706.

Brain Research
|July 1, 1988
PubMed
Summary

Rat intercostal nerves become excitable by day 13 of gestation, demonstrating action potential conduction before nerve-muscle contact. This early excitability is crucial for understanding neural development.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Embryology

Background:

  • Intercostal nerves are vital for respiration and motor control.
  • Understanding the developmental timeline of nerve excitability and myelination is key to identifying developmental disorders.

Purpose of the Study:

  • To investigate the physiological and morphological development of rat intercostal nerves during embryonic development.
  • To determine the onset of excitability and the sequence of myelination in these nerves.

Main Methods:

  • Electrophysiological recordings of action potentials in embryonic rat intercostal nerves.
  • Morphological analysis of nerve structure, including Schwann cell development and axon myelination, using microscopy.

Main Results:

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  • Rat intercostal nerves exhibit excitability via action potentials at 13 days of gestation, preceding functional neuromuscular junctions.
  • Sodium ions (Na+) are the primary charge carriers for action potentials, with a transient calcium ion (Ca2+) current present until day 18.
  • Schwann cell proliferation and ensheathment begin around 17-18 days, with myelination commencing at day 22 and completing postnatally.

Conclusions:

  • Nerve excitability is established before functional neuromuscular connections form.
  • The development of intercostal nerve excitability and myelination follows a specific temporal sequence during embryonic and early postnatal life.
  • This study provides critical insights into the early developmental stages of the peripheral nervous system.