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Related Concept Videos

Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

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Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
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Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
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Trends in lipid-modifying agent use in 83 countries.

Joseph E Blais1, Yue Wei1, Kevin K W Yap2

  • 1Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, University of Hong Kong, Hong Kong.

Atherosclerosis
|June 6, 2021
PubMed
Summary

Global use of lipid-modifying agents (LMAs) significantly increased from 2008 to 2018, with statins being the most common. However, clear links between LMA consumption and cholesterol levels remain limited.

Keywords:
Drug utilizationGlobal healthLipid-modifying agentsPharmacoepidemiologySales

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Area of Science:

  • Cardiovascular Medicine
  • Pharmacoeconomics
  • Public Health

Background:

  • Lipid-modifying agents (LMAs) are crucial for managing dyslipidemia and preventing cardiovascular events.
  • Global consumption patterns and regional variations in LMA use were previously unknown.
  • Understanding LMA trends is vital for public health strategies and resource allocation.

Purpose of the Study:

  • To analyze global trends in LMA consumption from 2008 to 2018.
  • To investigate the association between national LMA consumption and cholesterol levels.
  • To identify shifts in the utilization of different LMA classes.

Main Methods:

  • Ecological study utilizing pharmaceutical sales data from 83 countries (IQVIA) for 2008-2018.
  • Analysis of cholesterol concentrations (total and non-HDL) from the NCD Risk Factor Collaboration.
  • Calculation of Compound Annual Growth Rate (CAGR) to assess consumption changes over time.

Main Results:

  • Global LMA consumption rose by a CAGR of 4.13%, reaching 11,197 units per 1000 inhabitants in 2018.
  • Statins dominated LMA use, increasing market share in 75% of countries.
  • Rapid growth observed in newer therapies: ezetimibe (4.01% CAGR) and PCSK9 inhibitors (104.47% CAGR).

Conclusions:

  • Global access to LMAs, particularly statins, has improved since 2008.
  • Trends align with guidelines, showing increased use of statins, ezetimibe, and PCSK9 inhibitors.
  • Significant country-level variations exist in LMA use and cholesterol concentrations, with limited correlation observed.