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Specific sweat metabolite profile in ocular Behcet's disease
Xiaoxiao Cui1, Liming Zhang1, Guannan Su1
1The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, Chongqing Eye Institute, and Chongqing Branch of National Clinical Research Center for Ocular Diseases, Chongqing 400016, People's Republic of China.
International Immunopharmacology
|June 6, 2021
Summary
Researchers identified distinct sweat metabolite profiles in Behcet's disease (BD) patients, revealing potential biomarkers for this autoimmune disorder. This study highlights differences in sweat composition for improved BD understanding.
Area of Science:
- Biochemistry
- Immunology
- Analytical Chemistry
Background:
- Behcet's disease (BD) is a serious autoimmune disorder with potential for blindness.
- Understanding BD pathogenesis requires further research into its underlying mechanisms.
Purpose of the Study:
- To investigate the metabolite composition of sweat in Behcet's disease patients.
- To identify potential sweat biomarkers for Behcet's disease.
Main Methods:
- Metabolomics analysis was conducted on sweat samples.
- Liquid chromatography tandem mass spectrometry was employed.
- Samples were collected from 20 BD patients and 18 healthy controls.
Main Results:
- Significant differences in sweat metabolic profiles were observed between BD patients and healthy controls.
- Orthogonal partial least squared-discrimination analysis (OPLS-DA) effectively separated the groups.
- Candidate biomarkers identified include l-citrulline, l-pyroglutamic acid, urocanic acid, 2-oxoadipic acid, cholesterol 3-sulfate, and pentadecanoic acid.
Conclusions:
- This study presents the first report on sweat metabolite profiles in Behcet's disease.
- The findings demonstrate a significantly altered sweat metabolite composition in BD patients compared to healthy individuals.
