Related Experiment Video

Updated: Nov 3, 2025

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method
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MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method

Published on: October 7, 2025

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MicroRNAs as important contributors in the pathogenesis of colorectal cancer

Soudeh Ghafouri-Fard1, Bashdar Mahmud Hussen2, Elham Badrlou1

  • 1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|June 6, 2021
PubMed

Insights

MicroRNAs (miRNAs) are crucial in colorectal cancer (CRC) development, influencing key pathways and offering diagnostic potential. Further research is needed to explore their therapeutic applications in clinical settings.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Colorectal cancer (CRC) is a leading cause of cancer death globally.
  • Non-coding RNAs, particularly microRNAs (miRNAs), play significant roles in CRC pathogenesis.
  • miRNAs are implicated in regulating critical signaling pathways like TGF-β, Wnt/β-catenin, MAPK, and PI3K/AKT in CRC.

Purpose of the Study:

  • To provide an updated review on the involvement of miRNAs in colorectal cancer.
  • To summarize the diagnostic and prognostic applications of miRNAs in CRC.
  • To highlight the potential therapeutic roles of miRNAs in CRC.

Main Methods:

  • Literature review focusing on recent advancements in miRNA research related to CRC.
  • Analysis of studies investigating miRNA expression in biological samples (stool, serum) for CRC detection.
  • Examination of preclinical and clinical studies on miRNA-based therapeutics for CRC.

Main Results:

  • miRNAs are key regulators of CRC development and progression, interacting with other non-coding RNAs.
  • Circulating miRNAs in stool and serum show promise as diagnostic biomarkers for distinguishing CRC patients from healthy individuals.
  • While therapeutic strategies using miRNAs have shown potential in animal models, clinical validation is still pending.

Conclusions:

  • MicroRNAs are integral to the molecular landscape of colorectal cancer, influencing its development and progression.
  • miRNAs hold significant potential as non-invasive biomarkers for CRC diagnosis and prognosis.
  • Further clinical investigation is warranted to translate the therapeutic promise of miRNAs into effective treatments for colorectal cancer.
Keywords:
BiomarkerColorectal cancerMiRNAMicroRNA

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