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Oral and oropharyngeal lymphomas: A multi-institutional collaborative study
José Alcides Almeida de Arruda1, Lauren Frenzel Schuch1,2, Nicolau Conte Neto1
1Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Summary
Oral and oropharyngeal lymphomas are uncommon but diagnosed in this study of 304 cases. Diffuse large B-cell lymphoma (DLBCL) is the most frequent subtype, affecting older adults, primarily in the palate and jaw.
Area of Science:
- Oncology
- Hematology
- Pathology
Background:
- Lymphomas of the oral and oropharyngeal regions are rare and diagnostically challenging due to diverse histopathological subtypes.
- This study presents a large series of these lymphomas and compares findings with existing literature.
Purpose of the Study:
- To analyze the clinicodemographic and histopathological features of oral and oropharyngeal lymphomas.
- To compare the findings with the current body of scientific literature.
Main Methods:
- Retrospective retrieval of diagnosed lymphoma cases from seven Brazilian institutions.
- Evaluation of clinicodemographic data and histopathological features.
- Comprehensive literature review for comparative analysis.
Main Results:
- A total of 304 cases were analyzed, with the highest incidence in the 60-69 age group (68 cases).
- Mature B-cell neoplasms (87.2%) were most common, followed by mature T- and NK-cell neoplasms (11.2%).
- Diffuse large B-cell lymphoma, not otherwise specified (DLBCL, NOS), was the most frequent subtype (99 cases). Palate (26.3%), mandible (13%), and maxilla (10.5%) were the most affected sites.
Conclusions:
- DLBCL, NOS, is confirmed as the predominant lymphoma subtype in the oral and oropharyngeal regions.
- Older individuals are most affected, with no significant gender predilection.
- The palate and jaw are the most commonly involved anatomical sites.
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