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Updated: Nov 3, 2025

Contribution of the Na+/K+ Pump to Rhythmic Bursting, Explored with Modeling and Dynamic Clamp Analyses
Published on: May 9, 2021
Dynamic mechanism of multiple bursting patterns in a whole-cell multiscale model with calcium oscillations
Xiaowen Xiong1, Yanqiu Li1, Dongmei Zheng1
1School of Physical and Mathematical Sciences, Nanjing Tech University, Nanjing, People's Republic of China.
Abstract:
The dynamic mechanism of a whole-cell model containing electrical signalling and two-compartment Ca signalling in gonadotrophs is investigated. The transition from spiking to bursting by Hopf bifurcation of the fast subsystem about the slow variable is detected via the suitable parameters. When the timescale of K gating variable is changed, the relaxation oscillation with locally small fluctuation, chaotic bursting and mixed-mode bursting (MMB) are revealed through chaos. In addition, the bifurcation of with regard to is analysed, showing periodic solutions, torus, period doubling solutions and chaos. Finally, hyperpolarizations and torus canard-like behaviours of the full system under a set of specific parameters are elucidated.
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