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Synovial fluid Lipocalin-2 as a biomarker for chronic prosthetic joint infection: Prospective validation in hip and knee revision arthroplasty.

Revista espanola de cirugia ortopedica y traumatologia·2026
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[Translated article] Success after surgical treatment of unstable hip prosthesis: 12 years of experience in a third level hospital.

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Related Experiment Video

Updated: Nov 3, 2025

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Visual impairment induced by prosthetic cobaltism.

B F Sánchez-Dalmau1, F Spencer1, L Sánchez-Vela2

  • 1Institut Clínic d'Oftalmología, Hospital Clínic, Barcelona, Spain.

Archivos De La Sociedad Espanola De Oftalmologia
|June 7, 2021
PubMed
Summary

Prosthetic cobaltism, caused by hip implant degeneration, can lead to systemic cobalt absorption and multiple health issues, including vision loss. Early surgical intervention and chelation therapy can reverse these effects.

Keywords:
2,3-Dimercapto-1-propanesulfonic acid (DMPS)CobaltCobaltismo protésicoCobaltoDimercaptosuccinic acid (DMSA)Ethylenediaminetetraacetic acid (EDTA)Hip replacementProsthetic cobaltismPrótesis de caderaPérdida visualToxicidadToxicityVisual lossÁcido dimercaptosuccínico (DMSA)Ácido etilendiaminotetraacético (EDTA)Ácido2,3-Dimercapto-1-propanesulfónico (DMPS)

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Area of Science:

  • Biomedical Engineering
  • Toxicology
  • Ophthalmology

Background:

  • Metallic hip prostheses can degenerate over time.
  • Degeneration may lead to systemic absorption of cobalt.

Observation:

  • A 68-year-old patient presented with visual loss.
  • The patient had a history of a metallic hip prosthesis.

Findings:

  • Systemic cobalt absorption from the prosthesis caused prosthetic cobaltism.
  • Manifestations included cardiac, neurological, endocrine, auditory, and visual disorders.
  • Serum cobalt measurements confirmed the diagnosis.

Implications:

  • Early diagnosis and treatment are crucial for managing prosthetic cobaltism.
  • Surgical intervention and chelation therapy can improve visual and other systemic disorders.
  • This case highlights the importance of monitoring for metal-related complications from implants.