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Related Experiment Video

Updated: Nov 3, 2025

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

Published on: February 22, 2015

[Glioblastoma].

¹Department of Neurosurgery, Tokyo University.

No Shinkei Geka. Neurological Surgery

|June 7, 2021

Summary

This summary is machine-generated.

Glioblastoma treatment involves surgery, radiation, and chemotherapy. Novel therapies like NovoTTF and perampanel offer new hope for managing this aggressive brain cancer.

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Last Updated: Nov 3, 2025

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

Published on: February 22, 2015

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

Translational Orthotopic Models of Glioblastoma Multiforme

Translational Orthotopic Models of Glioblastoma Multiforme

Published on: February 17, 2023

Area of Science:

Neuro-oncology
Cancer Therapeutics
Medical Devices

Background:

Glioblastoma is the most common and malignant form of glioma, associated with a poor prognosis and median survival of approximately 1.5 years.
Standard treatment involves maximal safe resection, radiotherapy, and temozolomide chemotherapy.
Emerging therapies and supportive care strategies are crucial for improving patient outcomes.

Purpose of the Study:

To provide an overview of the multidisciplinary treatment approaches for glioblastoma.
To discuss novel therapeutic modalities and their mechanisms of action.
To explore future perspectives in glioblastoma management.

Main Methods:

Review of current and emerging glioblastoma treatments.
Description of surgical, radiological, and chemotherapeutic strategies.
Inclusion of novel devices and pharmaceutical agents.

Main Results:

Standard treatment combines surgery, radiotherapy, and temozolomide.
Bevacizumab and photodynamic therapy with talaporfin sodium are approved in Japan.
NovoTTF devices and perampanel show promise in preclinical studies for inhibiting tumor growth and invasion.

Conclusions:

Multidisciplinary treatment is essential for glioblastoma.
Novel therapies, including NovoTTF and perampanel, offer potential advancements.
Future research directions aim to improve glioblastoma survival rates and quality of life.