Multidomain Intervention for Reversal of Cognitive Frailty, Towards a Personalized Approach (AGELESS Trial): Study...

Area of Science:

• Gerontology and Cognitive Health
• Public Health Interventions
• Geriatric Medicine

Background:

• Cognitive frailty (CF) is a significant risk factor for dementia.
• Multidomain interventions show promise in delaying or preventing CF onset.

Purpose of the Study:

• To assess the effectiveness and cost-effectiveness of a comprehensive multidomain intervention for cognitive frailty.
• To identify factors influencing adherence to intensive interventions for older adults.

Main Methods:

• A randomized controlled trial involving 330 older adults with CF in Malaysia.
• A 24-month multidomain intervention (physical, nutritional, cognitive, psychosocial) versus usual care.
• Assessment of primary outcomes including CF status, physical function, cognition, and psychosocial/nutritional status.

Main Results:

• The multidomain intervention is anticipated to be cost-effective compared to usual care.
• The intervention is expected to demonstrate the ability to reverse cognitive frailty.

Conclusions:

• This trial contributes to the World-Wide FINGERS Network, enabling data harmonization.
• Effective intervention strategies will be integrated into a personalized telerehabilitation package for CF reversal.