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Interaction Between APOE Genotype and Diabetes in Longevity.

Mitsuru Shinohara1,2,3, Kaoru Suzuki1, Guojun Bu3

  • 1Department of Aging Neurobiology, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.

Journal of Alzheimer'S Disease : JAD
|June 7, 2021
PubMed
Summary

Diabetes shortens lifespan, especially in non-demented individuals, with effects varying by apolipoprotein E (APOE) genotype. Activity status is also impacted by diabetes, particularly in non-APOE4 carriers.

Keywords:
Apolipoprotein Edementiadiabeteslongevity

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Area of Science:

  • Genetics
  • Gerontology
  • Neuroscience

Background:

  • Apolipoprotein E (APOE) genotype and diabetes are known factors influencing longevity and Alzheimer's disease risk.
  • The interplay between APOE genotype and diabetes concerning lifespan and cognitive health requires further investigation.

Purpose of the Study:

  • To investigate the interaction between diabetes and APOE genotype on lifespan.
  • To examine the relationship between diabetes, APOE genotype, and cognitive status.

Main Methods:

  • Utilized the National Alzheimer's Coordinating Center (NACC) dataset, comprising longitudinal clinical records of 24,967 individuals.
  • Collected data on APOE genotype and diabetic status for all participants.

Main Results:

  • Diabetes was associated with reduced lifespan in APOE3 and APOE2 carriers, but not significantly in APOE4 carriers.
  • A significant interaction between cognitive status and diabetes affected lifespan, with diabetes showing harmful effects in non-demented individuals across APOE genotypes.
  • Diabetes impacted activity status significantly in non-APOE4 carriers, suggesting a link between lifestyle and longevity outcomes.

Conclusions:

  • The impact of diabetes on longevity is modulated by APOE genotype.
  • Diabetes exerts detrimental effects on lifespan in non-demented individuals, potentially linked to activity status.
  • Understanding these interactions is crucial for personalized longevity and Alzheimer's disease prevention strategies.