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Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment
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First 1000 Days of Life: Consequences of Antibiotics on Gut Microbiota

Julio Aires1,2

  • 1Université de Paris, INSERM, UMR-S1139 (3PHM), Paris, France.

Frontiers in Microbiology
|June 7, 2021
PubMed

Insights

Antibiotics given during the first 1000 days can disrupt the developing gut microbiota, potentially leading to long-term health issues. This review explores antibiotic impacts on early-life gut establishment and associated dysbiosis.

Area of Science:

  • Microbiology
  • Developmental Biology
  • Public Health

Background:

  • The first 1000 days (conception to 2 years) are critical for establishing gut microbiota.
  • Neonatal gut establishment is vulnerable to environmental factors.
  • Antibiotics are common perinatal exposures impacting gut colonization.

Purpose of the Study:

  • To review the impact of antibiotics on the developing intestinal microbiota.
  • To discuss the role of antibiotics in dysbiosis and long-term health consequences.

Main Methods:

  • Literature review focusing on perinatal and early-life antibiotic exposure.
  • Analysis of studies on gut microbiota establishment and function.
  • Examination of short- and long-term health outcomes linked to antibiotic-induced dysbiosis.

Main Results:

  • Antibiotics significantly alter gut bacterial colonization patterns.
  • Early-life antibiotic exposure can lead to persistent gut dysbiosis.
  • Dysbiosis is associated with various negative health outcomes.

Conclusions:

  • Antibiotic use during the critical first 1000 days poses risks to gut microbiota development.
  • Interventions to mitigate antibiotic effects on the neonatal gut are crucial.
  • Further research is needed to understand and manage long-term health consequences.

Keywords:
DOHaDantibioticsgut microbiotahealth consequencesresistome

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