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Updated: Nov 3, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Enantio- and diastereoselective diarylmethylation of 1,3-dicarbonyl compounds
Xin Li1, Songtao He1, Qiuling Song1
1Institute of Next Generation Matter Transformation, College of Materials Science & Engineering, Huaqiao University 668 Jimei Blvd Xiamen Fujian China qsong@hqu.edu.cn.
Abstract:
A Cu-catalyzed enantio- and diastereoselective diarylmethylation of 1,3-dicarbonyl compounds is described. It is a successful example of constructing all-carbon quaternary stereocenters from 3 °C-H nucleophiles, a challenging topic in synthetic chemistry. In the present work, two contiguous stereocenters are constructed with high levels of stereoselectivity and atom economy. The broad scope of 1,3-dicarbonyl nucleophiles and the tolerance of a wide range of functional groups make this protocol of great importance in the synthesis of chiral diarylmethane compounds.
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