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Updated: Nov 2, 2025

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
Published on: March 12, 2015
Triple the fun: tris(ferrocenyl)arene-based gold(i) complexes for redox-switchable catalysis
Axel Straube1, Peter Coburger1, Luis Dütsch2
1Institute of Inorganic Chemistry, Universität Leipzig Johannisallee 29 D-04103 Leipzig Germany hey@uni-leipzig.de https://anorganik.chemie.unileipzig.de/de/anorganik/ak-hey-hawkins/.
Abstract:
The modular syntheses of C 3-symmetric tris(ferrocenyl)arene-based tris-phosphanes and their homotrinuclear gold(i) complexes are reported. Choosing the arene core allows fine-tuning of the exact oxidation potentials and thus tailoring of the electrochemical response. The tris[chloridogold(i)] complexes were investigated in the catalytic ring-closing isomerisation of N-(2-propyn-1-yl)benzamide, showing cooperative behaviour vs. a mononuclear chloridogold(i) complex. Adding one, two, or three equivalents of 1,1'-diacetylferrocenium[tetrakis(perfluoro-tert-butoxy)aluminate] as an oxidant during the catalytic reaction (in situ) resulted in a distinct, stepwise influence on the resulting catalytic rates. Isolation of the oxidised species is possible, and using them as (pre-)catalysts (ex situ oxidation) confirmed the activity trend. Proving the intactness of the P-Au-Cl motif during oxidation, the tri-oxidised benzene-based complex has been structurally characterised.
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