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Radiosensitization using hydrogen peroxide in patients with cervical cancer
Rong Hu1, Anneyuko I Saito1, Taira Mitsuhashi1
1Department of Radiation Oncology, Juntendo University Faculty of Medicine, Bunkyo, Tokyo 113-8421, Japan.
Molecular and Clinical Oncology
|June 7, 2021
Summary
Hydrogen peroxide radiosensitization shows promise for cervical cancer patients unable to undergo brachytherapy, demonstrating good survival rates and tolerability in a small study.
Area of Science:
- Oncology
- Radiotherapy
- Gynecologic Oncology
Background:
- Radiosensitization enhances radiation therapy effectiveness.
- Hydrogen peroxide has shown efficacy in superficial tumors but not cervical cancer.
- Cervical cancer patients ineligible for brachytherapy need alternative treatments.
Purpose of the Study:
- To evaluate the feasibility and safety of hydrogen peroxide radiosensitization for cervical cancer.
- To assess survival outcomes and adverse events in patients receiving this combined treatment.
Main Methods:
- Twenty cervical cancer patients received radical external beam radiotherapy (RT) combined with topical 3% hydrogen peroxide.
- Treatment involved twice-weekly hydrogen peroxide application during RT.
- Radiation dose was 45 Gy in 25 fractions to the pelvis, with an optional 10 Gy boost.
Main Results:
- 18 patients were evaluated; 17 had evaluable tumors.
- One- and two-year overall survival rates were 90% for Stage I/II and 86% for Stage III/IV.
- Adverse events were well-tolerated with no severe acute or late complications.
Conclusions:
- Hydrogen peroxide radiosensitization appears feasible and safe for cervical cancer patients.
- This approach may offer an alternative for patients unable to undergo brachytherapy.
- Further research with larger sample sizes and longer follow-up is warranted.
