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Management of Lassa Fever: A Current Update
Ammar Alli1,2, Juan Fernando Ortiz3,4, Stephanie P Fabara5
1Medicine, Tishreen University Faculty of Medicine, Lattakia, SYR.
Cureus
|June 7, 2021
Summary
Lassa fever treatment primarily involves intravenous ribavirin for acute infections and oral ribavirin for post-exposure prophylaxis. More research is needed as Lassa fever (LF) gains attention.
Area of Science:
- Infectious Diseases
- Virology
- Public Health
Background:
- Lassa fever (LF) is a high-priority infectious disease designated by the FDA and WHO.
- Despite expert expectations of increased Lassa fever virus (LFV) infections, the disease receives limited global attention.
- Existing treatment strategies require further investigation and validation.
Purpose of the Study:
- To review Lassa fever treatment approaches documented in scientific literature over the past two decades.
- To identify the most effective management strategies for Lassa fever infection.
- To highlight research gaps and the need for updated clinical evidence.
Main Methods:
- Conducted a comprehensive literature search using Medical Subject Headings (MeSH) on PubMed.
- Included studies published in English and focused on human subjects.
- Analyzed and synthesized findings on various Lassa fever treatment modalities.
Main Results:
- Intravenous (IV) ribavirin is identified as the most effective treatment for acute Lassa fever.
- Oral ribavirin is recommended for post-exposure prophylaxis.
- Convalescent plasma lacks sufficient evidence for Lassa fever treatment recommendation.
Conclusions:
- Ribavirin, particularly IV administration, remains a cornerstone in acute Lassa fever management.
- Further clinical trials are essential to solidify evidence for ribavirin efficacy and other potential treatments.
- Increased scientific and global attention is crucial for addressing the growing threat of Lassa fever.
Keywords:
lassa fever
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