Related Experiment Video
Updated: Nov 2, 2025
10:28
Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
12.9K
Copper-based biomaterials for bone and cartilage tissue engineering
Yufeng Wang1,2, Wei Zhang2,3, Qingqiang Yao1,3
1Department of Orthopaedic Surgery, Institute of Digital Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China.
Journal of Orthopaedic Translation
|June 7, 2021
Summary
Copper biomaterials enhance bone and cartilage tissue engineering by improving scaffold properties and promoting cell growth. This review explores copper
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Regenerative Medicine
Background:
- Tissue engineering utilizes cells, scaffolds, and bioactive molecules for tissue repair.
- Copper is an essential element with increasing applications in tissue engineering due to its physiological roles.
Purpose of the Study:
- To review advances in copper-based biomaterials for bone and cartilage tissue engineering.
- To discuss copper's physiochemical and biological effects in these applications.
Main Methods:
- Literature search on PubMed and Web of Science for copper-based biomaterials in bone and cartilage tissue engineering.
Main Results:
- Various copper forms (ions, nanoparticles, alloys) improve scaffold properties (porosity, strength, degradation).
- Copper enhances cell migration, adhesion, osteogenesis, chondrogenesis, angiogenesis, and exhibits antibacterial activity.
- In vivo applications for bone and cartilage regeneration are discussed.
Conclusions:
- Copper incorporation offers tuneable properties and significant biological benefits for bone and cartilage regeneration.
- Future perspectives and limitations of copper in tissue engineering are addressed.
- Copper biomaterials can improve tissue generation, reduce infection risk, and shorten recovery times.
