Related Experiment Video

Updated: Nov 2, 2025

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

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FUT8-AS1 Inhibits the Malignancy of Melanoma Through Promoting miR-145-5p Biogenesis and Suppressing NRAS/MAPK

Xiang-Jun Chen1, Sha Liu1, Dong-Mei Han1

  • 1Department of Burns and Plastic Surgery, The 969th Hospital of PLA, Hohhot, China.

Frontiers in Oncology
|June 7, 2021
PubMed

Insights

FUT8-AS1 acts as a tumor suppressor in melanoma by inhibiting cell growth and metastasis. Its downregulation correlates with poor prognosis, suggesting it as a potential therapeutic target for skin cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Melanoma is a deadly skin cancer with unclear molecular drivers.
  • Identifying prognostic biomarkers is crucial for melanoma treatment.

Purpose of the Study:

  • To identify novel long non-coding RNAs (lncRNAs) involved in melanoma progression.
  • To elucidate the molecular mechanisms of FUT8-AS1 in melanoma.

Main Methods:

  • Analysis of The Cancer Genome Atlas (TCGA) data.
  • In vitro and in vivo functional assays.
  • Mechanistic studies involving RNA-protein interactions and signaling pathways.

Main Results:

  • FUT8-AS1 is downregulated in melanoma and associated with poor survival.
  • FUT8-AS1 suppresses melanoma cell proliferation, migration, invasion, growth, and metastasis.
  • FUT8-AS1 regulates the NF90/miR-145-5p/NRAS/MAPK signaling axis.

Conclusions:

  • FUT8-AS1 functions as a tumor suppressor in melanoma.
  • Targeting FUT8-AS1 and its downstream pathway offers potential therapeutic strategies for melanoma.
Keywords:
FUT8-AS1MAPK signalingNF90malignancymelanomamicroRNA biogenesis

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