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Neutrophil to Lymphocyte Ratio Is Increased and Associated With Left Ventricular Diastolic Function in Newly

Miao Hou1, Lei Cao1, Yueyue Ding1

  • 1Department of Cardiology, Children's Hospital of Soochow University, Suzhou, China.

Frontiers in Pediatrics
|June 7, 2021
PubMed

Insights

The neutrophil-to-lymphocyte ratio (NLR) is elevated in children with hypertension and correlates with blood pressure. This inflammatory marker may help assess cardiac diastolic function in hypertensive children.

Area of Science:

  • Pediatrics
  • Cardiology
  • Inflammation Biology

Background:

  • Hypertension in children can lead to cardiac structural and functional changes, such as left ventricular hypertrophy (LVH) and diastolic dysfunction.
  • The neutrophil-to-lymphocyte ratio (NLR) is an emerging inflammatory biomarker linked to cardiovascular diseases.

Purpose of the Study:

  • To investigate the neutrophil-to-lymphocyte ratio (NLR) in children with newly diagnosed essential hypertension.
  • To explore the relationship between NLR, blood pressure, and cardiac alterations in these children.

Main Methods:

  • A case-control study included 65 children with newly diagnosed essential hypertension and 54 healthy controls.
  • Echocardiography was used to assess left ventricular mass index (LVMI), LV systolic function (ejection fraction, fractional shortening), and LV diastolic function (E/E' ratio).
  • Blood cell counts and biochemical parameters were analyzed, with a focus on NLR.

Main Results:

  • Children with hypertension exhibited significantly higher LVMI and E/E' ratios compared to controls, indicating diastolic dysfunction.
  • The neutrophil-to-lymphocyte ratio (NLR) was significantly elevated in the hypertensive group and positively correlated with systolic and diastolic blood pressure.
  • NLR showed a significant positive correlation with the E/E' ratio, suggesting a link with diastolic dysfunction, but not with LVH or systolic function.

Conclusions:

  • The neutrophil-to-lymphocyte ratio (NLR) is elevated in children with essential hypertension.
  • NLR is positively associated with blood pressure levels and may serve as a useful marker for assessing left ventricular diastolic function in hypertensive children.

Keywords:
childrenhypertensionleft ventricular diastolic functionleft ventricular hypertrophyneutrophil-lymphocyte ratio

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