Related Experiment Video
Updated: Nov 2, 2025
08:48
Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
Published on: January 26, 2016
12.1K
Current Advancements in Sactipeptide Natural Products.
Yunliang Chen1,2, Jinxiu Wang3, Guoquan Li2
1State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Frontiers in Chemistry
|June 7, 2021
Summary
Ribosomally synthesized and post-translationally modified peptides (RiPPs), including sactipeptides, are diverse natural products. This review covers sactipeptide discovery, biosynthesis, and potential applications.
Area of Science:
- Natural Product Chemistry
- Biochemistry
- Molecular Biology
Background:
- Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a diverse class of natural products discovered through genome sequencing.
- RiPPs exhibit varied chemical structures and biological activities, sharing a common biosynthetic pathway involving precursor peptides and post-translational modifications.
- Sactipeptides, a subclass of RiPPs, are characterized by unique sulfur-to-alpha carbon thioether cross-links, conferring properties like antibacterial and hemolytic activities.
Purpose of the Study:
- To review recent advancements in the field of sactipeptides.
- To consolidate information on sactipeptide discovery, distribution, structural elucidation, and biosynthesis.
- To explore the potential applications of sactipeptides.
Main Methods:
- Literature review of recent research on sactipeptides.
- Analysis of biosynthetic pathways and enzymatic mechanisms.
- Compilation of data on sactipeptide structures and activities.
Main Results:
- Sactipeptides are formed through a conserved mechanism involving rSAM enzymes catalyzing thioether bond formation.
- Recent discoveries have expanded the known diversity and distribution of sactipeptides across various organisms.
- Elucidation of biosynthetic pathways provides insights into the generation of their complex structures.
Conclusions:
- Sactipeptides represent a promising class of natural products with significant potential for various applications.
- Continued research into sactipeptide biosynthesis and structure-activity relationships is crucial for unlocking their full potential.
- The review highlights the importance of interdisciplinary approaches in natural product discovery and development.
