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Related Experiment Videos

Ventricular interaction during experimental acute pulmonary embolism.

I Belenkie1, R Dani, E R Smith

  • 1Department of Medicine, University of Calgary, Alberta, Canada.

Circulation
|September 1, 1988
PubMed
Summary
This summary is machine-generated.

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Pulmonary embolism reduces left ventricular preload, not contractility. Transmural left ventricular end-diastolic pressure (LVEDP) accurately reflects preload, unlike standard LVEDP during embolism.

Area of Science:

  • Cardiovascular Physiology
  • Pulmonary Medicine
  • Hemodynamics

Background:

  • Acute pulmonary embolism often causes decreased stroke volume, with minimal changes in left ventricular end-diastolic pressure (LVEDP).
  • This suggests potential alterations in left ventricular compliance or contractility.

Purpose of the Study:

  • To investigate if reduced preload, mediated by increased pericardial constraint, is the primary cause of altered left ventricular function during pulmonary embolism.
  • To evaluate the reliability of LVEDP versus transmural LVEDP as an index of left ventricular preload.

Main Methods:

  • Hemodynamics and left ventricular (LV) chamber dimensions were measured in anesthetized dogs.
  • Measurements were taken during control volume loading, after induced pulmonary embolism, and after repeated pulmonary embolism in a volume-loaded state.

Related Experiment Videos

  • Sonomicrometry was used to assess chamber dimensions.

    • Main Results:

    • The correlation between LVEDP and LV end-diastolic volume index was poor.
    • The correlation between transmural LVEDP and LV end-diastolic volume index was significantly higher.
    • LV stroke work correlated better with transmural LVEDP than with LVEDP.

    Conclusions:

    • Left ventricular compliance and contractility are not substantially altered during acute pulmonary embolism.
    • Altered LV performance is primarily due to reduced LV preload, indicated by decreased transmural LVEDP.
    • Transmural LVEDP is a more accurate index of LV preload than LVEDP during pulmonary embolism.