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High-Frequency Ultrasound Echocardiography to Assess Zebrafish Cardiac Function
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Zebrafish Heart Failure Models.

Suneeta Narumanchi1, Hong Wang1, Sanni Perttunen1

  • 1Unit of Cardiovascular Research, Minerva Foundation Institute for Medical Research, Biomedicum Helsinki, Helsinki, Finland.

Frontiers in Cell and Developmental Biology
|June 7, 2021
PubMed
Summary

Zebrafish models offer valuable insights into heart failure and cardiac remodeling. This research reviews their utility in understanding disease mechanisms and developing novel therapies for heart conditions.

Keywords:
cardiac hypertrophycardiac remodelingcardiomyopathyheart failurezebrafish

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Area of Science:

  • Cardiovascular Biology
  • Comparative Medicine
  • Regenerative Medicine

Background:

  • Heart failure is a global health concern with incomplete understanding of its mechanisms and treatments.
  • Zebrafish share cardiac similarities with mammals and offer advantages for disease modeling, including rapid development and genetic tractability.
  • Zebrafish exhibit remarkable cardiac regeneration capabilities, yet their use in studying heart failure and remodeling remains underexplored.

Purpose of the Study:

  • To discuss the application of zebrafish models in studying heart failure and cardiac remodeling.
  • To review existing zebrafish models for heart failure, including genetic and drug-induced approaches.
  • To evaluate the strengths and limitations of zebrafish in modeling human heart disease.

Main Methods:

  • Review of existing literature on zebrafish heart failure models.
  • Discussion of genetic manipulation techniques (morpholinos, CRISPR-Cas9) for studying gene function in vivo.
  • Analysis of various zebrafish heart failure models, encompassing genetic, drug-induced, and injury-based approaches.

Main Results:

  • Zebrafish models provide a powerful platform for investigating heart failure pathomechanisms.
  • The review highlights the advantages of zebrafish, such as ease of observation, genetic manipulation, and regeneration.
  • Specific models are discussed, detailing their utility and limitations in mimicking human cardiac pathologies.

Conclusions:

  • Zebrafish models are instrumental in advancing the understanding of heart failure and cardiac remodeling.
  • Further utilization of these models can uncover novel therapeutic targets and strategies.
  • The insights gained from zebrafish research hold promise for developing innovative treatments for heart failure.