Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chromatin.

G Felsenfeld

    Nature
    |January 12, 1978
    PubMed
    Summary
    This summary is machine-generated.

    The nucleosome

    Related Experiment Videos

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Chromatin structure, epigenetic mechanisms and long-range interactions in the human insulin locus.

    Diabetes, obesity & metabolism·2012
    Same author

    Chromatin boundaries, insulators, and long-range interactions in the nucleus.

    Cold Spring Harbor symposia on quantitative biology·2010
    Same author

    Chromatin boundaries and chromatin domains.

    Cold Spring Harbor symposia on quantitative biology·2005
    Same author

    Chromatin goes global.

    Molecular cell·2001
    Same author

    Correlation between histone lysine methylation and developmental changes at the chicken beta-globin locus.

    Science (New York, N.Y.)·2001
    Same author

    Transitions in histone acetylation reveal boundaries of three separately regulated neighboring loci.

    The EMBO journal·2001
    Same journal

    Incoming US science academy chief vows to 'double down' on research.

    Nature·2026
    Same journal

    Author Correction: Synthesis of enantioenriched atropisomers by biocatalytic deracemization.

    Nature·2026
    Same journal

    Electrodeposited self-assembled molecules for perovskite photovoltaics.

    Nature·2026
    Same journal

    Neutrino's nursery found: the 'Shadow Blaster'.

    Nature·2026
    Same journal

    Dementia risk in middle-aged people linked to a blood protein.

    Nature·2026
    Same journal

    Daily briefing: What's really happening with trust in science.

    Nature·2026
    See all related articles

    Area of Science:

    • Molecular biology
    • Genetics
    • Biochemistry

    Background:

    • The nucleosome, the basic unit of DNA packaging, has a known overall structure.
    • However, the precise internal organization of DNA within the nucleosome remains unclear.
    • Histones, particularly arginine-rich ones, are known to be crucial for DNA folding.

    Purpose of the Study:

    • To elucidate the internal architecture of the nucleosome.
    • To understand the role of histone proteins in DNA organization within the nucleosome.
    • To investigate the involvement of nucleosomes in DNA replication and transcription.

    Main Methods:

    • Analysis of recent studies on nucleosome organization.
    • Examination of DNA folding mechanisms mediated by histones.
    • Investigation of nucleosome presence during DNA replication and transcription.

    Main Results:

    • Details of DNA organization within the nucleosome have been revealed.
    • Arginine-rich histones are confirmed as essential for DNA folding.
    • Nucleosomes are implicated at sites of DNA replication and transcription.

    Conclusions:

    • Nucleosome internal architecture is crucial for DNA packaging.
    • Interactions within and between nucleosomes are vital for DNA replication and transcription processes.