Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

5.4K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
5.4K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

78.0K
Overview
78.0K
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

1.2K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
1.2K
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

13.7K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
13.7K
Humoral Immune Responses01:36

Humoral Immune Responses

79.1K
Overview
79.1K
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

3.6K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cribriform plate microenvironment assembles a suppressive myeloid network during EAE-induced neuroinflammation.

eLife·2026
Same author

Targeting fibrosis in the treatment of lower urinary tract dysfunction.

The Journal of pathology·2026
Same author

VEGFR Blockade Reduces <i>Mycobacterium tuberculosis</i>-Induced Lung Pathology in Immunocompromised Mice.

Cells·2026
Same author

Cribriform Plate Microenvironment Assembles a Suppressive Myeloid Network during EAE-induced Neuroinflammation.

bioRxiv : the preprint server for biology·2026
Same author

The cribriform plate: A dynamic central nervous system-immune hub.

The Journal of experimental medicine·2025
Same author

Perineural immune environment of olfactory nerves is reshaped by neuroinflammatory drainage and connects to ethmoid bone marrow.

Science advances·2025

Related Experiment Video

Updated: Nov 2, 2025

Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment
09:00

Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment

Published on: June 24, 2020

3.5K

Current concepts in granulomatous immune responses.

Melinda Herbath1, Zsuzsanna Fabry1, Matyas Sandor1

  • 1Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, USA.

Biologia Futura
|June 7, 2021
PubMed
Summary

Granulomas form when the body encounters persistent irritants, creating lesions that can protect or harm the host. Understanding granuloma formation offers new therapeutic strategies for related diseases.

Keywords:
VEGFcell trafficdendritic cellsgranuloma

More Related Videos

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays
06:03

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

1.5K
Isolation Protocol of Mouse Monocyte-derived Dendritic Cells and Their Subsequent In Vitro Activation with Tumor Immune Complexes
11:48

Isolation Protocol of Mouse Monocyte-derived Dendritic Cells and Their Subsequent In Vitro Activation with Tumor Immune Complexes

Published on: May 31, 2018

11.7K

Related Experiment Videos

Last Updated: Nov 2, 2025

Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment
09:00

Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment

Published on: June 24, 2020

3.5K
Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays
06:03

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

1.5K
Isolation Protocol of Mouse Monocyte-derived Dendritic Cells and Their Subsequent In Vitro Activation with Tumor Immune Complexes
11:48

Isolation Protocol of Mouse Monocyte-derived Dendritic Cells and Their Subsequent In Vitro Activation with Tumor Immune Complexes

Published on: May 31, 2018

11.7K

Area of Science:

  • Immunology
  • Cell Biology
  • Pathology

Background:

  • Granulomas are macrophage-dominated lesions that form in response to persistent irritants resistant to innate and cognate immunity.
  • These lesions isolate host tissue from inflammation but can cause damage, contributing to over a hundred human diseases.
  • Particles, toxins, autoantigens, and infectious agents are common inducers of granuloma formation.

Purpose of the Study:

  • To review recent discoveries in molecular mechanisms of granuloma formation.
  • To discuss the differences between innate and cognate granuloma pathways.
  • To explore how the dendritic cell-T cell axis influences granulomatous immunity.

Main Methods:

  • Literature review summarizing recent molecular discoveries.
  • Comparative analysis of innate and cognate granuloma pathways.
  • Discussion of the role of the dendritic cell-T cell axis in granulomatous immunity.

Main Results:

  • New molecular mechanisms for macrophage transformation into granuloma-inducing cells have been identified.
  • Insights into the initiation, spread, and regulation of granuloma lesions.
  • Granuloma lesions are dynamic, requiring continuous cell replacement.

Conclusions:

  • Understanding granuloma dynamics and regulation provides novel therapeutic avenues.
  • The interplay between the dendritic cell-T cell axis and granulomatous immunity is crucial.
  • Targeting the dynamic nature of granulomas offers potential treatments for granulomatous diseases.