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Updated: Nov 2, 2025
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A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
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Adrenal venous sampling with adrenocorticotropic hormone stimulation: A meta-analysis
Junfeng Yang1, Yanhong Yu1, Zhuorui Zhang1
1Department of Urology, First People's Hospital of Yunnan Province, Kunming, China.
International Journal of Clinical Practice
|June 7, 2021
Summary
Adrenal venous sampling with adrenocorticotropic hormone stimulation improves accuracy for primary aldosteronism diagnosis. This method significantly reduces incorrect lateralization and cannulation failures compared to sampling without stimulation.
Area of Science:
- Endocrinology
- Medical Diagnostics
- Surgical Procedures
Background:
- Primary aldosteronism is a condition requiring accurate diagnosis.
- Adrenal venous sampling (AVS) is a key diagnostic procedure.
- The role of adrenocorticotropic hormone (ACTH) stimulation in AVS is debated.
Purpose of the Study:
- To compare the efficacy of AVS with and without ACTH stimulation.
- To assess the impact of ACTH on diagnostic accuracy and procedural success.
Main Methods:
- Systematic literature search up to May 2020.
- Meta-analysis of 17 studies including 1878 subjects.
- Calculation of odds ratios (OR) with 95% confidence intervals (CIs).
Main Results:
- AVS with ACTH stimulation showed significantly lower incorrect lateralization (OR, 0.57).
- ACTH stimulation reduced unsuccessful cannulations of both adrenal veins (OR, 0.35), left (OR, 0.10), and right (OR, 0.25).
Conclusions:
- ACTH stimulation during AVS significantly improves diagnostic accuracy and procedural success in primary aldosteronism.
- Larger prospective studies are recommended to validate these findings.
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