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Exercise and platelet intracellular free calcium concentration
S M Barr1, K R Lees, D D McBryan
1University Department of Materia Medica, Stobhill General Hospital, Glasgow, U.K.
Clinical Science (London, England : 1979)
|August 1, 1988
Summary
Exercise increases blood pressure but does not alter platelet intracellular free calcium concentration ([Ca2+]i). This study investigated the relationship between acute exercise-induced blood pressure changes and platelet calcium levels.
Area of Science:
- Cardiovascular Physiology
- Hematology
Background:
- A known correlation exists between elevated blood pressure and increased platelet intracellular free calcium concentration ([Ca2+]i).
- The impact of acute exercise on this specific physiological parameter remains less understood.
Purpose of the Study:
- To investigate the effect of acute exercise-induced blood pressure fluctuations on platelet intracellular free calcium concentration ([Ca2+]i).
Main Methods:
- Twenty-one subjects underwent controlled exercise on a bicycle ergometer.
- Blood pressure, heart rate, catecholamines, lactate, and platelet [Ca2+]i were measured at rest, immediately post-exercise, and at 30 minutes and 1 hour post-exercise.
Main Results:
- Significant increases in systolic and diastolic blood pressure, heart rate, plasma lactate, and catecholamines were observed during exercise.
- No significant alterations in platelet intracellular free calcium concentration ([Ca2+]i) were detected throughout the study period.
Conclusions:
- Acute changes in blood pressure associated with moderate-intensity exercise do not appear to influence platelet intracellular free calcium concentration ([Ca2+]i).
- This suggests that the mechanisms linking blood pressure and platelet calcium may not be acutely activated by exercise in healthy individuals.