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Updated: Nov 2, 2025

Single-channel Analysis and Calcium Imaging in the Podocytes of the Freshly Isolated Glomeruli
Published on: June 27, 2015
A novel class for carbonic anhydrases inhibitors and evaluation of their non-zinc binding
Burak Kuzu1, Meltem Tan1, İlhami Gülçin2
1Pharmaceutical Chemistry Section, Van Yüzüncü Yil University, Van, Turkey.
Abstract:
In this study, 23 different imidazole derivatives were synthesized, and the inhibitory properties of these derivatives against carbonic anhydrase I and II isoenzymes were investigated for the first time. The inhibition concentrations of the imidazole derivatives were found to be in the range of 2.89-115.5 nM. Docking studies examined the binding properties of the imidazole derivatives, and the structure-activity relationship is discussed. Theoretical calculations showed that the binding mode of the imidazole ring was non-zinc binding.
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