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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Papillary Dermis01:11

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Lichen planus - a clinical guide.

Farzan Solimani1, Stephan Forchhammer2, Alexandra Schloegl2

  • 1Department of Dermatology, Venereology and Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
|June 7, 2021
PubMed
Summary
This summary is machine-generated.

Lichen planus (LP) is a chronic inflammatory skin and mucosal disorder with limited treatment options. Research into LP pathogenesis may reveal new therapeutic targets for this challenging condition.

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Area of Science:

  • Dermatology
  • Immunology
  • Pathogenesis

Background:

  • Lichen planus (LP) is a chronic inflammatory disorder affecting skin, mucosa, and appendages.
  • Characterized by T-cell infiltration in the upper dermis, LP presents diverse subtypes.
  • Current therapeutic options for LP, especially mucosal and scalp variants, are often inadequate, leading to a significant psychosocial burden.

Purpose of the Study:

  • To provide a comprehensive clinical guide on Lichen Planus.
  • To summarize current clinical knowledge and therapeutic standards for LP management.
  • To discuss future perspectives and potential therapeutic targets for LP.

Main Methods:

  • Review of current clinical knowledge on Lichen Planus.
  • Analysis of therapeutic standards for various LP subtypes.
  • Discussion of emerging research on LP pathogenesis and potential drug targets.

Main Results:

  • Lichen planus remains a therapeutic enigma with limited effective treatments, particularly for recalcitrant mucosal and scalp forms.
  • Understanding LP pathogenesis is advancing, identifying potential new therapeutic targets.
  • Current management strategies are discussed alongside future therapeutic avenues.

Conclusions:

  • Lichen planus presents significant therapeutic challenges, necessitating further research.
  • Advances in understanding disease pathogenesis offer hope for novel treatment strategies.
  • This guide consolidates current knowledge and future directions for LP management.