Computer simulation of fluid resuscitation in trauma. I. Description of an extensive pathophysiological model and its...

Computer-based 'patient simulators' are of a potential value in diagnosis, monitoring and therapy of the severely ill patient with trauma. An extensive pathophysiological model is described and documented in full detail. The model makes it possible to calculate and predict clinically important state variables on the basis of fluid input and fluid losses. Sample runs are presented for illustrations in hemorrhage, fluid and salt loading.