Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

3.4K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
3.4K
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal01:22

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

2.4K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.4K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

4.5K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
4.5K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

1.4K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
1.4K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

898
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
898
Allergic Reactions02:06

Allergic Reactions

29.5K
Overview
29.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inflammatory conditions determine glucocorticoid effects on spontaneous or immunoglobulin-induced neutrophil death.

Pharmacology·2026
Same author

Multiplex Cytokine LTT Reveals Strong T Cell Responses to Multiple Drugs in NIDHR-Associated Multiple Drug Hypersensitivity.

The journal of allergy and clinical immunology. In practice·2026
Same author

Update of the evidence- and consensus-based S3 guideline on atopic dermatitis: Systemic therapy with biologics or Janus kinase inhibitors and specific aspects of systemic therapy in pregnancy and lactation.

Allergologie select·2026
Same author

Refractory acute generalized exanthematous pustulosis-Successfully treated with bimekizumab.

JAAD case reports·2026
Same author

Pharmacy-based triage to preselect high-risk individuals for skin cancer screening: A pilot study.

Journal of the European Academy of Dermatology and Venereology : JEADV·2026
Same author

Altered crosstalk of bacterial lipopolysaccharide with immune cells in colorectal cancer compared to paired adjacent intestinal tissue.

Gut microbes·2026

Related Experiment Video

Updated: Nov 2, 2025

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
03:23

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Published on: May 10, 2024

1.1K

Eosinophils in skin diseases.

Susanne Radonjic-Hoesli1, Marie-Charlotte Brüggen2,3,4, Laurence Feldmeyer1

  • 1Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Seminars in Immunopathology
|June 7, 2021
PubMed
Summary

Eosinophils, normally absent in skin, infiltrate various skin diseases. This review details their pathogenic roles and therapeutic targets in eosinophil-associated dermatoses.

Keywords:
EosinophilGranule proteinsHost defenseImmunoregulationTissue damage

More Related Videos

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
05:44

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

425
Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation
08:44

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Published on: May 30, 2020

6.3K

Related Experiment Videos

Last Updated: Nov 2, 2025

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
03:23

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Published on: May 10, 2024

1.1K
Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
05:44

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

425
Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation
08:44

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Published on: May 30, 2020

6.3K

Area of Science:

  • Dermatology
  • Immunology
  • Pathology

Background:

  • Eosinophils are typically absent in healthy skin but infiltrate numerous skin diseases.
  • Cutaneous eosinophilia can be reactive (cytokine-mediated) or result from clonal eosinophil expansion due to mutations.
  • Eosinophils play active roles in host defense, immune regulation, pruritus, tissue remodeling, and damage.

Purpose of the Study:

  • To review the clinical presentations of eosinophil-associated dermatoses.
  • To elucidate the pathogenic role of eosinophils in these skin diseases.
  • To discuss current and emerging therapies targeting eosinophils.

Main Methods:

  • This is a review article, synthesizing existing research.
  • It analyzes mechanisms of eosinophil involvement in skin disease pathogenesis.
  • Clinical presentations and therapeutic strategies are discussed.

Main Results:

  • Eosinophils contribute to bacterial/viral clearance, blister formation, T-cell recruitment, and pruritus generation.
  • Their multifaceted roles highlight their capacity to drive disease pathogenesis.
  • Understanding these mechanisms informs targeted therapeutic approaches.

Conclusions:

  • Eosinophil infiltration is a significant feature across diverse dermatoses.
  • Eosinophils actively contribute to the pathogenesis of skin diseases through various mechanisms.
  • Targeting eosinophils represents a promising therapeutic avenue for eosinophil-associated dermatoses.