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Associations of Sleep Characteristics with Cerebrospinal Fluid sTREM2 in Cognitively Normal Older Adults: the CABLE

He-Ying Hu1, Ling-Zhi Ma1, Hao Hu1

  • 1Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.

Neurotoxicity Research
|June 7, 2021
PubMed

Insights

Poor sleep quality and duration are linked to higher levels of soluble triggering receptor expressed on myeloid cells 2 (sTREM2) in cognitively normal older adults, particularly those with amyloid plaques. This suggests sleep influences neuroinflammation.

Area of Science:

  • Neuroscience
  • Immunology
  • Sleep Medicine

Background:

  • Sleep disturbances can exacerbate neuroinflammation by activating microglia.
  • Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) in cerebrospinal fluid (CSF) reflects microglial activity.
  • Understanding the link between sleep and microglial responses is crucial for brain health.

Purpose of the Study:

  • To investigate the association between sleep characteristics and CSF sTREM2 levels in cognitively normal older adults.
  • To explore these associations in relation to amyloid pathology (amyloid-positive vs. amyloid-negative).

Main Methods:

  • Linear and non-linear regression analyses were performed on 830 participants.
  • Sleep characteristics were assessed using the Pittsburgh Sleep Quality Index (PSQI) and sleep-time measures.
  • CSF sTREM2 levels were measured and analyzed alongside cognitive status and APOE4 genotype.

Main Results:

  • Positive linear associations were found between sleep efficiency and CSF sTREM2 in all participants.
  • In amyloid-positive individuals, poorer sleep quality and efficiency were linked to higher CSF sTREM2.
  • U-shaped relationships were observed between sleep duration/timing and CSF sTREM2 in amyloid-positive individuals.

Conclusions:

  • Poor self-reported sleep is associated with elevated CSF sTREM2, indicating increased microglial activity.
  • Sleep plays a significant role in regulating TREM2-associated microglial responses, especially in the presence of amyloid pathology.
  • These findings highlight sleep as a potential target for mitigating neuroinflammation.
Keywords:
AmyloidCerebrospinal fluidInflammationMicrogliaSleepsTREM2

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