International Council for Standardisation in Haematology (ICSH) recommendations for collection of blood samples for...

Area of Science:

• Clinical Laboratory Science
• Hematology
• Preanalytical Variables

Background:

• Accurate coagulation testing is critical for patient diagnosis and management.
• Standardized preanalytical procedures are essential for reliable laboratory results.
• Existing guidelines may not comprehensively address all aspects of blood sample collection for coagulation tests.

Purpose of the Study:

• To provide international guidance and recommendations for collecting blood samples for coagulation tests.
• To standardize the preanalytical phase of coagulation testing in clinical laboratories worldwide.
• To address key factors influencing the quality of blood samples for coagulation analysis.

Main Methods:

• Development of guidance based on published data in peer-reviewed literature.
• Incorporation of expert opinion from the International Council for Standardisation in Haematology (ICSH).
• Systematic review of precollection and collection variables impacting coagulation sample integrity.

Main Results:

• Detailed recommendations are provided for test ordering, tube selection, patient preparation, and collection devices.
• Guidance covers venous stasis, order of draw, sample labeling, and blood-to-anticoagulant ratios.
• The influence of hematocrit on coagulation test results is discussed.

Conclusions:

• Adherence to these standardized collection procedures is crucial for accurate coagulation testing.
• This guidance aims to improve the quality of blood samples and reduce preanalytical errors.
• Implementation of these recommendations will enhance the reliability of coagulation test results in clinical laboratories.