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Ovarian toxicity of nanoparticles
Ramsés Santacruz-Márquez1, Marijose González-De Los Santos1, Isabel Hernández-Ochoa1
1Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav), Av. Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, Ciudad de México 07360, Mexico.
Reproductive Toxicology (Elmsford, N.Y.)
|June 7, 2021
Summary
Nanoparticle exposure can harm female fertility by affecting ovarian functions. Understanding nanoparticle physicochemical properties is crucial for assessing reproductive risks.
Area of Science:
- Reproductive Toxicology
- Nanomedicine
- Ovarian Biology
Background:
- The ovary is vital for female reproduction, regulating hormone synthesis, follicular development, and oocyte competence.
- Nanoparticle (NP) use is widespread, leading to unavoidable exposure.
- NP accumulation in ovarian tissue may impair reproductive functions.
Purpose of the Study:
- To review NP accumulation in ovarian tissue.
- To summarize NP toxicity to ovarian functions (hormone production, follicular development, oocyte quality, fertility).
- To highlight the role of NP physicochemical characteristics in ovarian toxicity.
Main Methods:
- Literature review of studies on NP-ovarian interactions and toxicity.
- Analysis of NP physicochemical properties influencing toxicity.
- Summary of NP toxicity mechanisms in ovarian cells.
Main Results:
- Evidence suggests NPs can accumulate in ovarian tissue.
- NP exposure can negatively impact sex steroid hormone production, follicular development, oocyte quality, and fertility.
- Physicochemical characteristics of NPs significantly influence their ovarian toxicity.
Conclusions:
- NP accumulation in the ovary poses a risk to female reproductive health.
- Physicochemical properties of NPs are critical determinants of ovarian toxicity.
- Further research is needed to understand NP-ovary interactions and develop safety guidelines.
