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Updated: Nov 2, 2025

Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
Preparation and optimization of fast disintegrating tablets of isosorbide dinitrate using lyophilization method for
Mitra Alami-Milani1,2, Sara Salatin1,2, Elaheh Nasiri2
1Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Abstract:
Background: Orally disintegrating tablets rapidly disintegrate in saliva and then swallowed without the need for water. Materials & methods: The orally disintegrating tablets were prepared by freeze-drying of an aqueous dispersion of isosorbide dinitrate containing a matrix former (gelatin), a cryoprotectant (mannitol), a plasticizer (glycerin) and a dissolution enhancer (Tween/polyethylene glycol). Results: Results demonstrated that the selected formulation, Ft9, disintegrated within 1 min and showed faster dissolution rate compared with the commercial tablet. Conclusion: Having a fast disintegration time, the developed lyophilized tablet does not need to be swallowed as a whole. So, it is a convenient solid oral dosage form for the patients who have difficulty with swallowing such as the pediatric and elderly ones.
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