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Updated: Nov 2, 2025
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Lipidomics and Transcriptomics in Neurological Diseases
Published on: March 18, 2022
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New insights into human prefrontal cortex aging with a lipidomics approach
Mariona Jové1, Natalia Mota-Martorell1, Pascual Torres1
1Department of Experimental Medicine, University of Lleida-Lleida Biomedical Research Institute (Udl-irblleida), Lleida, Spain.
Expert Review of Proteomics
|June 8, 2021
Summary
Lipidomics reveals how lipid changes in the human prefrontal cortex (hPFC) contribute to cognitive decline during aging. Membrane damage and cellular dysfunction in hPFC are linked to aging-related cognitive impairment.
Area of Science:
- Neuroscience
- Gerontology
- Biochemistry
Background:
- The human prefrontal cortex (hPFC) is crucial for cognitive functions, which decline with age.
- Molecular mechanisms of hPFC neural cell aging and cognitive decline are not fully understood.
Purpose of the Study:
- To review the role of lipids in hPFC aging.
- To discuss lipidomics approaches for analyzing brain tissue.
- To examine interventions targeting lipid metabolism in aging hPFC.
Main Methods:
- Lipidomics analysis of brain tissue.
- Review of existing literature on hPFC lipid profiles and aging.
Main Results:
- The hPFC possesses a unique lipid profile shaped by evolution.
- Lipid membrane damage and subsequent cellular dysfunction are implicated in age-related cognitive decline in hPFC.
Conclusions:
- Lipidomics is essential for understanding brain aging.
- Dysfunctional lipid metabolism contributes significantly to cognitive decline in the aging hPFC.
Keywords:
Advanced lipoxidation end productsagingcognitive declinelipid oxidationlipidomicsmass spectrometryreactive carbonyl speciesMore Related Videos
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