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Updated: Aug 3, 2026

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
Published on: February 8, 2022
Ventricular septal defect with overriding aorta in trisomy-18
R J Moene1, M Sobotka-Plojhar, A Oppenheimer-Dekker
1Department of Paediatric Cardiology, Free University Hospital, Amsterdam, The Netherlands.
Abstract:
In a child with trisomy-18 prenatal echocardiography demonstrated the presence of a ventricular septal defect with overriding aorta. In a previous anatomical study of 18 hearts with this malformation we found a 50% concurrence rate with trisomy-18. In case of prenatal echocardiographic detection of a ventricular septal defect with overriding aorta, we advise thorough ultrasound examination for additional malformations as seen in trisomy-18; subsequently this procedure should be completed by cytogenetic analysis of amniotic cells.
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