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Fluorescence-based Monitoring of PAD4 Activity via a Pro-fluorescence Substrate Analog
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The polarity protein PARD3 and cancer
Farzaneh Atashrazm1, Sarah Ellis2
1Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC, Australia. f.atashrazm@gmail.com.
Oncogene
|June 8, 2021
Summary
Partition defective 3 (PARD3) regulates cell polarity and tissue organization. This review explores PARD3
Area of Science:
- Cell Biology
- Cancer Research
- Molecular Oncology
Background:
- Tissue disorganization is a hallmark of cancer.
- Polarity proteins, like Partition defective 3 (PARD3), control cell arrangement in epithelial tissues.
- PARD3 acts as a master regulator of the Par polarity complex and a scaffolding protein for signaling molecules.
Purpose of the Study:
- To review the dual role of PARD3 in tumorigenesis.
- To discuss PARD3's involvement in various solid cancers.
- To explore the mechanisms underlying PARD3's function in cancer.
Main Methods:
- Literature review of laboratory and clinical studies.
- Analysis of PARD3's scaffolding functions.
- Examination of PARD3's association with signaling pathways and cell division.
Main Results:
- PARD3 can act as either a tumor suppressor or promoter.
- Its function is dependent on physiological and cellular context.
- PARD3 interacts with deregulated signaling molecules in cancer.
Conclusions:
- PARD3 plays a complex, context-dependent role in cancer development.
- Understanding PARD3's mechanisms is crucial for cancer research.
- Further investigation into PARD3's interactions is warranted.
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