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Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection
Published on: June 5, 2021
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Naturally enhanced neutralizing breadth to SARS-CoV-2 after one year.
Biorxiv : the Preprint Server for Biology
|June 8, 2021
Summary
Immunity to SARS-CoV-2 in recovered individuals is long-lasting. Vaccination of these individuals enhances antibody responses, providing protection against current and emerging COVID-19 variants.
Area of Science:
- Immunology
- Virology
- Public Health
Background:
- The COVID-19 pandemic caused by SARS-CoV-2 continues despite vaccine availability.
- Emerging variants pose challenges due to increased transmissibility and antibody resistance.
Approach:
- A cohort of 63 COVID-19-convalescent individuals were studied over 12 months.
- 41% of participants received mRNA vaccines, and humoral responses were assessed.
Key Points:
- Antibody reactivity and neutralizing activity remained stable from 6 to 12 months post-infection without vaccination.
- mRNA vaccination boosted humoral responses, including neutralizing activity against variants.
- Mechanisms include antibody mutation, B cell turnover, and selection of broadly neutralizing antibodies.
Conclusions:
- Immunity in convalescent individuals appears to be very long-lasting.
- Vaccinated convalescent individuals develop robust antibody and memory B cell responses protective against SARS-CoV-2 variants.
