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Updated: Nov 2, 2025

Intracranial Injection of Adeno-associated Viral Vectors

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Published on: November 17, 2010

ANCA-associated vasculitis after COVID-19.

Tugba Izci Duran¹, Ercan Turkmen², Melda Dilek²

¹Division of Rheumatology, Department of Internal Medicine, Ondokuz Mayıs University Medical Faculty, Korfez Mahallesi, 55270, Atakum/Samsun, Turkey. drtugbaizciduran@gmail.com.

Rheumatology International

|June 8, 2021

Summary

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may trigger antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). This report details two rare cases of new-onset AAV following COVID-19, highlighting potential links and treatment approaches.

Keywords:

Anti-neutrophil cytoplasmic antibody-associated vasculitis/diagnosis*COVID-19 Glomerulonephritis/pathology*SARS-CoV-2*

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Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia

Published on: December 19, 2020

Area of Science:

Nephrology
Immunology
Infectious Diseases

Background:

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) are systemic autoimmune diseases.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can trigger or worsen autoimmune conditions.
Crescentic glomerulonephritis (GN) is a rare complication of Coronavirus disease-2019 (COVID-19).

Observation:

Two cases of new-onset AAV following COVID-19 infection are presented.
Case 1: A 26-year-old male with acute kidney injury and anti-myeloperoxidase antibodies post-COVID-19.
Case 2: A 36-year-old female with hearing loss, lung lesions, acute kidney injury, and anti-proteinase-3 antibodies post-COVID-19.

Findings:

Both patients exhibited necrotizing GN with cellular crescents on kidney biopsy.
Treatment involved immunosuppressants (methylprednisolone, cyclophosphamide) and plasma exchange in one case.
Literature review identified four additional cases of new-onset AAV linked to COVID-19.

Implications:

COVID-19 may precipitate new-onset AAV, including pauci-immune GN.
Early diagnosis and immunosuppressive treatment are crucial for managing AAV post-COVID-19.
Further research is needed to understand the mechanisms linking SARS-CoV-2 infection and AAV development.