Related Experiment Video
Updated: Nov 2, 2025
09:49
Methods to Explore the Influence of Top-down Visual Processes on Motor Behavior
Published on: April 16, 2014
26.5K
Compressed sensorimotor-to-transmodal hierarchical organization in schizophrenia
Debo Dong1, Dezhong Yao1,2, Yulin Wang3,4
1The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of China, China.
Psychological Medicine
|June 8, 2021
Summary
Schizophrenia shows a compressed cortical hierarchy, disrupting sensory and cognitive systems. This brain organization imbalance impacts information processing and executive functions in patients.
Area of Science:
- Neuroscience
- Cognitive Neuroscience
- Systems Neuroscience
Background:
- Schizophrenia traditionally viewed as a high-order cognitive disorder.
- Emerging evidence highlights early sensory processing deficits.
- Recent models link sensory impairments to cognitive dysfunction.
Purpose of the Study:
- Investigate system-level imbalance in schizophrenia.
- Examine disruption of macroscale cortical hierarchy.
- Assess integration/segregation of unimodal and transmodal networks.
Main Methods:
- Used resting-state fMRI in 96 patients and 122 controls.
- Applied connectome gradient and stepwise connectivity analysis.
- Characterized sensorimotor-to-transmodal cortical hierarchy.
Main Results:
- Demonstrated cortical hierarchy compression in schizophrenia.
- Observed diminished separation between sensory and cognitive systems.
- Found reduced differentiation, hypo-connectivity in unimodal regions, and hyper-connectivity between regions.
Conclusions:
- Cortical hierarchy compression is a novel substrate for schizophrenia's sensory-cognitive interaction.
- Abnormal hierarchy suggests cascading impairments from sensory-motor disruption.
- Inefficient information integration contributes to cognitive deficits in schizophrenia.
Related Concept Videos
01:11Sensory Perception: Organization of the Somatosensory System
9.2K
The somatosensory system is the central and peripheral nervous system component that senses and processes touch, pressure, pain, temperature, and body position or proprioception. The process of sensation takes place at three levels:
The receptor level:
The receptor level is the first stage of sensation. It involves the detection of a stimulus by specialized sensory receptors. The stimulus must arrive within the receptor's receptive field. Next, the receptor converts the energy of the...
The receptor level:
The receptor level is the first stage of sensation. It involves the detection of a stimulus by specialized sensory receptors. The stimulus must arrive within the receptor's receptive field. Next, the receptor converts the energy of the...
9.2K
01:30Positive Symptoms of Schizophrenia: Hallucinations and Delusions
254
Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
254
01:33Somatosensation
41.3K
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
41.3K
01:24Somatosensory, Motor, and Association Cortex
1.3K
The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at...
1.3K
01:18Hierarchy of Motor Control
4.4K
The hierarchy of motor control refers to the different levels of organization and processing involved in controlling movement in the body. These levels range from higher cortical areas involved in planning and decision-making to lower spinal cord reflexes that respond automatically to external stimuli.
4.4K
01:27Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
1.3K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
1.3K