[Immunomodulating properties of khlotazol]

A nonsteroidal anti-inflammatory agent khlotazol administered to rats in doses of 40-80 mg/kg for 5 days stimulated synthesis of IgM- and IgG-antibodies to ram erythrocytes and increased the number of antibody-forming cells (AFC) and rosette-forming cells (RFC) in the spleen. When the doses were increased to 160-320 mg/kg, the stimulating effect of the drug on the production of hemagglutinins retained but dose-dependent inhibition of the number of AFC and RFC was found. When administered in a dose of 80 mg/kg khlotazol markedly activated the reaction of hypersensitivity of delayed type induced by ram erythrocytes.