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[Immunomodulating properties of khlotazol].
Farmakologiia I Toksikologiia
|May 1, 1988
Summary
Khlotazol, a nonsteroidal anti-inflammatory drug, stimulates antibody production at lower doses but inhibits immune cells at higher doses in rats. It also activates delayed-type hypersensitivity reactions.
Area of Science:
- Immunology
- Pharmacology
Background:
- Nonsteroidal anti-inflammatory drugs (NSAIDs) can modulate immune responses.
- Understanding the immunomodulatory effects of specific NSAIDs like khlotazol is crucial for their therapeutic application.
Purpose of the Study:
- To investigate the dose-dependent effects of khlotazol on humoral immunity and delayed-type hypersensitivity in rats.
Main Methods:
- Rats were administered varying doses of khlotazol (40-320 mg/kg) for 5 days.
- Humoral immune response was assessed by measuring IgM and IgG antibodies to ram erythrocytes.
- The number of antibody-forming cells (AFC) and rosette-forming cells (RFC) in the spleen was quantified.
- Delayed-type hypersensitivity reactions were induced and measured.
Main Results:
- Low doses (40-80 mg/kg) of khlotazol stimulated IgM and IgG antibody synthesis and increased splenic AFC and RFC.
- Higher doses (160-320 mg/kg) maintained hemagglutinin production but caused dose-dependent inhibition of AFC and RFC.
- A dose of 80 mg/kg khlotazol significantly activated the delayed-type hypersensitivity reaction.
Conclusions:
- Khlotazol exhibits a biphasic immunomodulatory effect, stimulating antibody production at lower doses and inhibiting immune cell proliferation at higher doses.
- The drug can activate delayed-type hypersensitivity reactions.
- These findings highlight the complex immunological impact of khlotazol, suggesting careful dose consideration in therapeutic contexts.