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Differential splicing in the 3' non-coding region of rat cytochrome P-452 (P450 IVA1) mRNA
D Earnshaw1, J W Dale, P S Goldfarb
1Department of Biochemistry, University of Surrey, Guildford, England.
FEBS Letters
|August 29, 1988
Abstract:
The gene coding for the clofibrate-induced cytochrome P-452 has been isolated from a cDNA library and a full-length cDNA clone sequenced. The sequence was identical with that reported by Hardwick et al. [(1987) J. Biol. Chem. 262, 801-810] apart from the presence of an additional 75 nucleotides inserted adjacent to the 3'-end of the coding region. Northern blot analysis indicates that this is probably a consequence of differential splicing, which may be relevant to the tissue-specific regulation of this gene.