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Assessing Therapeutic Angiogenesis in a Murine Model of Hindlimb Ischemia
Published on: June 8, 2019
Cost factors in limb-threatening ischaemia due to infrainguinal arteriosclerosis
S K Gupta1, F J Veith, E Ascer
1Department of Surgery, Montefiore Medical Center/Albert Einstein College of Medicine, New York, NY 10467.
Insights
Infrainguinal atherosclerosis treatment via vascular reconstruction or amputation is costly. Limb salvage rates were high, but associated costs were significant, especially with risk factors like gangrene or advanced age.
Area of Science:
- Vascular Surgery
- Health Economics
- Atherosclerosis Research
Background:
- Limb-threatening ischemia due to infrainguinal atherosclerosis affects over 150,000 US patients annually.
- Cost is a critical factor in managing medical conditions, including peripheral arterial disease.
- Understanding the economic impact of treatment options is vital for patient care and resource allocation.
Purpose of the Study:
- To evaluate the economic impact of treating limb-threatening ischemia caused by infrainguinal atherosclerosis.
- To compare the costs and outcomes of vascular reconstruction versus primary below-knee amputation.
- To identify cost-associated risk factors in patients with severe peripheral arterial disease.
Main Methods:
- Retrospective study of 313 consecutive patients treated between 1979-1981.
- Minimum 3-year follow-up to assess limb salvage and functional outcomes.
- Analysis of patient costs, length of stay, and risk factor impact on expenditure.
Main Results:
- Vascular reconstruction achieved limb salvage with full function in 79% at 1 year and 60% at 3 years.
- Mean cost for arterial reconstructions was $26,194; mean length of stay was 50 days.
- Risk factors like gangrene, age >70, and prior surgery significantly increased costs; below-knee amputation had high long-term costs for nonambulatory patients.
Conclusions:
- Both vascular reconstruction and primary amputation for infrainguinal atherosclerosis are associated with substantial costs.
- Vascular reconstruction offers high limb salvage rates, but carries significant financial implications.
- Adverse risk factors increase treatment costs, highlighting the need for cost-effective management strategies.
Abstract:
Cost factors are an increasingly important aspect of medical care. In the United States, more than 150,000 patients per year have limb-threatening ischaemia due to infrainguinal atherosclerosis. We studied the economic impact of this disease process and its treatment in 313 consecutive patients seen at our hospital between 1979 and 1981. Minimum follow-up was 3 years. Seventy-nine percent of our patients undergoing revascularisation attempts had limb salvage with full function at 1 year and 60% had full function at 3 years. Of the patients who died, 85% died with their limbs intact. The mean patient cost for all 289 arterial reconstructions was $26,194 +/- $876 S.E. ($23,026 +/- $1117 for 166 femoropopliteal bypasses; $30,380 +/- $1349 for 123 distal bypasses). The mean length of stay (LOS) for the reconstruction group was 50 days. In this patient population, the following adverse risk factors were present: Gangrene or necrosis in the foot (72%), age more than 70 (56%), and previous vascular surgery (21%). A significantly higher cost was associated with each of these factors (gangrene, $32,653 +/- $1534; age greater than 70, $28,089 +/- $1235; previous bypass, $29,666 +/- $1962). During the same time period, initial patient costs for 24 patients undergoing primary below-knee amputation and rehabilitation were $27,225 +/- $2896 S.E. Twenty-nine percent of the patients with below-knee amputations never walked again. The nonambulatory patients had a significant continuing expenditure for institutionalisation ($100/day) or home care ($270/week). These facts document the high cost of limb-threatening arteriosclerosis and its treatment by vascular reconstruction or primary below-knee amputation.(ABSTRACT TRUNCATED AT 250 WORDS)
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