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Updated: Nov 2, 2025

Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures
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Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439

David M Shackleford1, Francis C K Chiu1, Kasiram Katneni1

  • 1Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, Victoria 3052, Australia.

ACS Infectious Diseases
|June 8, 2021
PubMed

Keywords:
OZ439 (artefenomel)cytochrome P450 inhibitioncytochrome P450 metabolismmalariametabolite identificationtime-dependent inhibition

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