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Preparation of Rhenium-188-Lipiodol Using Freeze-Dried Kits for Transarterial Radioembolization: An Overview and
Edathurutykalarickal Ramakurup Radhakrishnan1, Viju Chirayil2, Arun Pandiyan1
1Kovai Medical Centre and Hospital, Coimbatore, India.
Cancer Biotherapy & Radiopharmaceuticals
|June 8, 2021
Summary
This study evaluated three freeze-dried kits for preparing Rhenium-188-lipiodol, a liver cancer radiopharmaceutical. A modified diethyl dithiocarbamate kit demonstrated superior yield and purity, offering practical advantages for clinical use.
Area of Science:
- Radiopharmaceutical Chemistry
- Nuclear Medicine
- Oncology
Background:
- Rhenium-188(188Re)-lipiodol is an effective radiopharmaceutical for liver cancer Selective Internal Radiation Therapy.
- Evaluating different radiolabeling kits is crucial for optimizing its clinical application.
Purpose of the Study:
- To assess the radiochemical performance, quality control, and ease of preparation of three commercial freeze-dried kits for 188Re-lipiodol.
- To compare the efficacy of acetylated 4-hexadecyl-4,7-diaza-1,10-decanedithiol (AHDD), super six sulfur (SSS), and diethyl dithiocarbamate (DEDC) kits.
Main Methods:
- Preparation of 188Re-lipiodol using AHDD, SSS, and DEDC kits with 188Re-sodium perrhenate from a 188W/188Re generator.
- Evaluation of overall yield and radiochemical purity (RCP) for each kit.
- Assessment of a modified DEDC kit for improved performance.
Main Results:
- All kits yielded >70% 188Re-lipiodol. SSS kit showed the highest initial yield (87.55%) and RCP (92.92%).
- A modified DEDC kit achieved a comparable yield (87.17%) with superior RCP (95.43%).
- The modified DEDC kit offers advantages in preparation time and handling of 188Re activity concentrations.
Conclusions:
- All evaluated kits are suitable for 188Re-lipiodol preparation, with SSS and DEDC kits performing well.
- The modified DEDC kit presents practical benefits for hospital radiopharmacies, particularly for preparing patient doses with low radioactive concentrations.
