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Relationship between BCG vaccination and increased mortality from COVID-19. An ecological fallacy?
Miguel Ángel Villasís-Keever1, María Guadalupe Miranda-Novales1
1Instituto Mexicano del Seguro Social, Unidad de Investigación en Análisis y Síntesis de la Evidencia, Coordinación de Investigación en Salud, Ciudad de México, México.
Abstract:
Ecological studies are one of the most common study designs used to establish the association between certain factors and disease development. However, they have limitations mainly on how to measure the variables, so their results must be verified in studies with greater validity. Therefore, the study that links the possible relationship between higher mortality from COVID-19 and non-vaccination by bacillus Calmette-Guérin (BCG) that was recently published, remains in doubt due to the lack of rigor in the methodology used.
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