Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

127
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
127
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

109
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
109
Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

115
 The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
115
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

390
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
390
Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

5.7K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
5.7K
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

3.4K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative efficacy and safety of olezarsen versus volanesorsen for familial chylomicronemia syndrome: a matching-adjusted indirect comparison.

Journal of comparative effectiveness research·2026
Same author

In Vivo Base Editing of <i>PCSK9</i> with VERVE-102 for Hypercholesterolemia.

The New England journal of medicine·2026
Same author

Clinical Diabetic Peripheral Neuropathy: Can It Be Reversed? Arguments for and Against From a NEUROdiab Debate.

Journal of the peripheral nervous system : JPNS·2026
Same author

Global survey of genetic testing methods for familial hypercholesterolemia. A study and recommendations from the EAS FHSC registry.

European journal of preventive cardiology·2026
Same author

Interrelationship Between Socioeconomic Status, Depression, and Neuropathy in People with Diabetes: A Cross-Sectional Study.

Journal of clinical medicine·2026
Same author

Impacts of the Urban Wastewater Discharges on the Indus River Basin: Water Quality Assessment and GIS Pollution Mapping.

Water environment research : a research publication of the Water Environment Federation·2026

Related Experiment Video

Updated: Nov 2, 2025

Lipidomics and Transcriptomics in Neurological Diseases
09:58

Lipidomics and Transcriptomics in Neurological Diseases

Published on: March 18, 2022

3.7K

Lipids and peripheral neuropathy.

Zohaib Iqbal1,2, Bilal Bashir2, Maryam Ferdousi1,2

  • 1Faculty of Biology, Medicine and Health, University of Manchester.

Current Opinion in Lipidology
|June 8, 2021
PubMed
Summary

High blood lipids, especially high triglycerides, contribute to nerve damage. Lipid-lowering therapies show promise in halting neuropathy progression and potentially regenerating nerve fibers, warranting further research.

More Related Videos

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF
03:42

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF

Published on: March 29, 2024

1.8K
Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF
07:05

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF

Published on: February 23, 2024

3.5K

Related Experiment Videos

Last Updated: Nov 2, 2025

Lipidomics and Transcriptomics in Neurological Diseases
09:58

Lipidomics and Transcriptomics in Neurological Diseases

Published on: March 18, 2022

3.7K
Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF
03:42

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF

Published on: March 29, 2024

1.8K
Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF
07:05

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF

Published on: February 23, 2024

3.5K

Area of Science:

  • Neurology
  • Metabolic Disorders
  • Pharmacology

Background:

  • Hyperlipidaemia is a known risk factor for developing neuropathy.
  • Altered lipid metabolism is mechanistically linked to peripheral nerve dysfunction.
  • Current treatments lack FDA-approved disease-modifying therapies for diabetic neuropathy.

Purpose of the Study:

  • To review the evidence on hyperlipidaemia and lipid-lowering therapy in peripheral neuropathy.
  • To explore the role of lipid modulation as a therapeutic target for diabetic nerve damage.

Main Methods:

  • Review of experimental and clinical studies.
  • Analysis of post hoc data from clinical trials of lipid-lowering pharmacotherapy.
  • Examination of outcomes from studies on statins, fibrates, and PCSK9 inhibitors.
  • Inclusion of data on bariatric surgery and its effects on neuropathy.

Main Results:

  • Dyslipidaemia negatively impacts nerve fibers, causing somatic and autonomic neuropathy.
  • Hypertriglyceridemia has a stronger association with peripheral neuropathy than LDL-C.
  • Lipid-lowering therapies (statins, fibrates) show beneficial or neutral effects.
  • PCSK9 inhibitors may offer protection against small fiber neuropathy.
  • Bariatric surgery improves neuropathy and promotes small nerve fiber regeneration, inversely correlating with triglyceride changes.

Conclusions:

  • Hyperlipidaemia, particularly hypertriglyceridemia, drives neuropathy development and progression.
  • Lipid-modifying agents are potential therapeutic options for peripheral neuropathy.
  • Further randomized controlled trials are needed to confirm the efficacy of intensive lipid lowering in nerve regeneration and symptom improvement.