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Related Concept Videos

  • Agricultural, Veterinary And Food Sciences
  • Veterinary Sciences
  • Veterinary Medicine (excl. Urology)
  • Biliary Motility Associated With Gallbladder Storage And Duodenal Delivery Of Canine Hepatic Biliary Output.
  • Agricultural, Veterinary And Food Sciences
  • Veterinary Sciences
  • Veterinary Medicine (excl. Urology)
  • Biliary Motility Associated With Gallbladder Storage And Duodenal Delivery Of Canine Hepatic Biliary Output.

    • Related Experiment Videos

    Biliary motility associated with gallbladder storage and duodenal delivery of canine hepatic biliary output.

    R B Scott1, S C Diamant

    • 1Department of Pediatrics, University of Calgary, Alberta, Canada.

    Gastroenterology
    |October 1, 1988

    View abstract on PubMed

    Summary
    This summary is machine-generated.

    The gallbladder and sphincter of Oddi regulate bile flow. Bile is stored in the gallbladder during fasting and released into the duodenum upon eating, involving sphincter of Oddi relaxation and gallbladder contraction.

    Related Experiment Videos

    Area of Science:

    • Gastroenterology
    • Digestive Physiology
    • Biliary System Dynamics

    Background:

    • Hepatic bile is partitioned between the gallbladder for storage and the duodenum for digestion.
    • The roles of the gallbladder (GB) and sphincter of Oddi (SO) in regulating this partition are not fully understood.

    Purpose of the Study:

    • To investigate the function of the GB and SO in controlling biliary output distribution between the GB and duodenum.
    • To analyze these functions during both interdigestive and postprandial states.

    Main Methods:

    • Utilized [14C]taurocholic acid infusion in dogs to trace hepatic bile acid output.
    • Employed duodenal marker perfusion to quantify GB filling/emptying and duodenal bile delivery.
    • Performed manometry on the SO, common duct, GB, and duodenum.

    Main Results:

    • During fasting, the GB stored most bile, with partial emptying and increased duodenal delivery occurring late in the migrating motor complex cycle.
    • SO relaxation and decreased pressure, alongside increased GB pressure, facilitated bile release.
    • Feeding triggered rapid SO relaxation, GB contraction, and maximal bile delivery within 10 minutes, suggesting a cephalic phase.

    Conclusions:

    • Both interdigestive and postprandial increases in duodenal bile delivery are mediated by SO relaxation and GB contraction.
    • Immediate postprandial changes indicate a cephalic phase influencing SO and GB motility for bile acid delivery.