Polyketide pesticides from actinomycetes
Shanshan Li1, Bowen Yang2, Gao-Yi Tan2
1State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Current Opinion in Biotechnology
|June 8, 2021
Summary
Polyketide pesticides from actinomycetes are gaining popularity due to their effectiveness and safety. This review covers their development, activities, and production, aiding future advancements in natural pesticides.
Area of Science:
- Agricultural Science
- Biotechnology
- Natural Product Chemistry
Background:
- Natural product-derived pesticides are increasingly favored globally for their high efficacy, environmental friendliness, and safety.
- Polyketide pesticides synthesized by actinomycetes have seen significant development and application in crop protection over recent decades.
- Examples of successful polyketide pesticides include avermectins, spinosyns, polynactins, and tetramycin.
Purpose of the Study:
- To review the development and activities of polyketide pesticides derived from actinomycetes.
- To provide insights into the engineering strategies and industrial production status of these natural pesticides.
- To highlight the potential of actinomycetes as a source for novel and improved pesticide solutions.
Main Methods:
- Literature review of scientific publications on polyketide pesticides from actinomycetes.
- Analysis of pesticide activities, discovery processes, and production advancements.
- Discussion of genetic engineering and strain improvement techniques for enhanced yield.
Main Results:
- Polyketide pesticides from actinomycetes demonstrate significant efficacy in crop protection.
- Biotechnology advancements have continuously improved the discovery and production of these natural pesticides.
- Various engineering strategies are being employed to optimize the industrial production of these compounds.
Conclusions:
- Actinomycetes are a rich source of bioactive secondary metabolites with pesticide potential.
- Further development of polyketide pesticides from actinomycetes is facilitated by understanding their production and improvement strategies.
- Continued research into strain improvement and engineering holds promise for sustainable agriculture.
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