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Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
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[Research progress on anti-tumor mechanism of tumor treating fields]

Y Y Liu1, H Wu2, J L Liu2

  • 1Medical School of Chinese PLA,Beijing 100853,China.

Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery]
|June 8, 2021
PubMed

Insights

Tumor treating fields (TTFields) disrupt cancer cell division by affecting microtubule dynamics. Emerging research reveals additional anti-tumor mechanisms and synergistic potential with drugs, expanding TTFields applications.

Area of Science:

  • Oncology
  • Biophysics
  • Cell Biology

Background:

  • Tumor treating fields (TTFields) are an FDA-approved cancer therapy.
  • The primary known mechanism involves disrupting microtubule dynamics during mitosis.
  • Recent research suggests broader anti-tumor effects beyond mitotic interference.

Purpose of the Study:

  • To elucidate the multifaceted anti-tumor mechanisms of TTFields.
  • To explore the potential of TTFields in combination therapies.
  • To identify optimal TTFields parameters for diverse cancer treatments.

Main Methods:

  • Review of existing literature on TTFields mechanisms.
  • Analysis of studies investigating TTFields' effects on cell membranes and BBB permeability.
  • Exploration of ongoing multi-system research into TTFields parameters.

Main Results:

  • TTFields primarily inhibit cancer cell division by interfering with microtubule dynamics.
  • TTFields demonstrate immunological and molecular anti-tumor activities.
  • TTFields can reversibly increase cell membrane and blood-brain barrier permeability, enhancing drug efficacy.

Conclusions:

  • TTFields possess diverse anti-tumor mechanisms beyond mitotic disruption.
  • Combination therapy with TTFields and anti-cancer drugs shows synergistic potential.
  • Further research will refine TTFields application for broader patient benefit.

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